Vol. 3, Issue 6 (2019)
Synthesis and characterization of copper (ii) complex: Dna binding, nuclease and superoxide dismutase activity
Author(s): Vikesh Kumar Singh, Anandveer Sindhu
Abstract: A tridentate ligand L1 (N,1-di(pyridin-2-yl)methylamine) was converted into complex 2, copper complex of two picolinate anion. Ligand L1 was reacted with CuCl2·2H2O in presence of triethylamine and a facile oxidation of azomethine function to carboxylic acid was observed. The resultant complex 2 afforded superoxide dismutase (SOD) activity and IC50 value was found to be 2.60 mM in xanthine/xanthine oxidase nitroblue tetrazolium assay. This small molecule SOD mimic exhibited nuclease activity by cleaving pBR322 DNA oxidatively in presence of 2-mercaptoethanol.