International Journal of Chemical Science

International Journal of Chemical Science


International Journal of Chemical Science
International Journal of Chemical Science
Vol. 5, Issue 3 (2021)

Comparative studies on conventional and microwave assisted synthesis of N-(phenylcarbamothioyl) benzamide derivatives and its anti-inflammatory activity


Shivani Khairmode, Radha Khade, Firoj Tamboli, Harinath More, Dhanashri Patil, Karuna Dhuri, Namrata Kanse, Shrinivas Mohite

The current research work was aimed to design and development of substituted N- (phenylcarbamothioyl) benzamide derivatives by QSAR approach and its In-vitro anti-inflammatory activity. The series of substituted N-(phenylcarbamothioyl) benzamide derivatives (2a1-2a4) was designed, and synthesized by using conventional and microwave method.The percentage yield by microwave assisted method was more compared to conventional method.TLC and IR spectra of synthesized products was performed and showed satisfactory results. In vitro anti-inflammatory activity of synthesized products was done by protein denaturation method.
Pages : 01-03