Synthesis, physicochemical and spectroscopic analysis of macrocyclic complexes of Fe (III) bearing nitrogen and oxygen as donor atoms and their antimicrobial screening
Sangeeta Lamba, Anita Kumari, Swati Bugalia
In this work, we have synthesized some new oxaazamacrocyclic complexes of iron (III) by metal template condensation synthesis method. [1+1] cyclocondensation reaction of 1,13-diamino,4,7,10-trioxatridecane and various α- diketones such as 2,3-butanedione, 2,3-pentanedione, 3,4-hexanedione,1-phenyl-1,2-propanedione, benzil or 4,4′-dimethylbenzil precursors in presence of FeCl3 [1:1:1] forms N2O3-macrocyclic complex of iron (III).The synthesized complexes characterized by elemental analyses, molar conductance, magnetic measurement, electronic, IR, H1-NMR and mass spectral studies. On the basis of spectral data a six coordinate distorted octahedral geometry has been proposed for all these complexes. Antimicrobial screening of all these complexes have also been carried out by taking some pathogenic bacteria strain Streptomyces griseus (gram-positive, MTCC-706), Escherichia coli (gram-negative, MTCC-1652), Staphylococcus aureus (gram-positive, MTCC-737) and Pseudomonas aeruginosa (gram-negative, MTCC-1688) and fungal strain Trichoderma Reesei (MTCC-164), Aspergillus niger (MTCC-282), Penicillium funicolusum (MTCC-1013) and Fusarium oxysporium (MTCC-2480). It is observed that Fe(III) complexes show more inhibitory activity than the ligand. All the complexes showed higher activities against S. griseus and E. coli.