A novel PVDF-Sil-IL membrane was created and applied to isolate cresol in solution with an electrically driven device. The effects of several variables such as the type of salts, voltage, time, pH and temperature were experimentally evaluated. The FT-IR proved the PVDF-Sil-IL membrane was successfully prepared. And under the optimized condition (20V of voltage, 20min of isolation, neutral pH and 40^oC of system), 90% of cresol was isolated. This finding can facilitate the development of PVDF membrane as an efficient electrochemistry tool for the isolation of phenols compounds from water samples.