1,3,4-Oxadiazole is a five membered heterocyclic nucleus and is considered to be derived from furan by replacement of two methane (-CH=) group by pyridine type nitrogen. 1,3,4-Oxadiazole is a versatile lead compound for scheming potent bioactive agents. The derivative of oxadiazole nucleus (1,3,4-oxadiazole) showed various biological activities such as antimicrobial, anti-inflammatory, antitubercular, anticonvulsant, anticancer, anti-HIV, hypoglycemic and genotoxic activities. In this article, an attempt is made to compile some of the major researches carried out for the compound 1,3,4- oxadiazole. 1,3,4-oxadiadole have produced interest in synthetic organic and medicinal chemistry as surrogates of carboxylic acid.