Ximenia americana was investigated in an attempt to evaluate its medicinal potential. The phytochemical constituents of ethanol extract reveals, the presence of Carbohydrates, Reducing sugar, Alkaloids, Saponins, Tannins, Steroids, Flavonoids and Terpenes. More so, the percentage yield of the extract reveals that ethanol yielded 25.1%. The antimalaria result showed that the activity of the extract is cytotoxic for Plasmodium falciparum, at 5000mg/ml and 2000mg/ml with a percentage (%) elimination of 86.4% and 74.5% respectively, when compared with the Standard with percentage elimination of 88.6% and 84.2%. The higher percentage elimination of the extract justify it antimalaria activity. While that of 1000mg/ml and 500mg/ml may also show growth elimination. The result of the phytochemicals study validates the use of ethanol extract of this species in ethno medicine and could provide a lead in the isolation of novel drugs candidate from ethanol extract of the plant.