International Journal of Chemical Science

Authors
Himanshu Joshi, Pranav Sharma, Pankaj Yadav, Ashish Yadav

Abstract
Coumarins have a long history of having number of pharmacological activities such as anticoagulant, antithrombotic, antimutagenic, vasodilator, LOX and CLOX inhibitors and it can also used in treatment of edema. The recent success of Coumarins as anti-inflammatory and anticoagulant has further highlighted the importance of this class in medicinal chemistry. Systematic investigation of this class of compound revealed that coumarin derivatives containing pharmacophore agent plays an important role in medicinal chemistry. This prompted to me, to synthesize new derivatives of Coumarins, 4-Chloro-3- coumarinaldehyde was reacted with halogens substituted aniline and rectified spirit to obtain a new series of 4-chloro-(3-substituted-phenylimino)-methyl-coumarin. A total of 6 compounds were synthesized. Their structures were confirmed by, 1H-NMR and Mass spectroscopy.