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VOL. 6, ISSUE 1 (2022)
Multicomponent synthesis of 1, 2, 4-trizole-dihydropyrimidinone derivatives using Biginelli cycloaddition reaction
Authors
Kabeer Shaikh, Yogesh Salve
Abstract
An operationally simple protocol was employed for synthesis of series of new 1, 2, 4-triazole-dihydropyrimidinone derivatives. Firstly 1-(4-(1H-1, 2, 4-triazol-1-yl) phenyl) ethanone was synthesized using 4-fluroacetophenone, 1, 2, 4-triazole, an.K2CO3 in DMF solvent for 12 hrs at 1100C. then 1-(4-(1H-1,2,4-triazol-1-yl)phenyl) ethanone was refluxed with dimethyl foramide dimethylacetal (DMF-DMA) for 6 hrs gives product 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-3-(dimethylamino)prop-2-en-1-one (enaminone). Lastly different substituted aromatic aldehyde, urea and 1-(4-(1H-1, 2, 4-triazol-1-yl) phenyl)-3-(dimethylamino) prop-2-en-1-one (enaminone) was refluxed in glacial acetic acid for 12 hrs yields series of new 1,2,4-triazole-dihydropyrimidinone derivatives. The synthesized compound were characterized by mass, 1H NMR and 13C NMR spectroscopy followed by antibacterial and antifungal activity.
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Pages:10-15
How to cite this article:
Kabeer Shaikh, Yogesh Salve "Multicomponent synthesis of 1, 2, 4-trizole-dihydropyrimidinone derivatives using Biginelli cycloaddition reaction ". International Journal of Chemical Science, Vol 6, Issue 1, 2022, Pages 10-15
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