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VOL. 7, ISSUE 2 (2023)
Comparative analysis of MOFs in chemical catalysis and biomedical applications
Authors
Dr. Randhir Kumar
Abstract
Coordination compounds have emerged as versatile
and multifunctional systems with significant applications in both catalysis and
targeted drug delivery. The present study investigates the structural,
electronic, and functional properties of coordination compounds, with
particular emphasis on their dual role in catalytic processes and biomedical
applications. A systematic review-based methodology was adopted, utilising data
from major scientific databases including SpringerLink, ScienceDirect, PubMed,
Scopus, and Web of Science. A total of 560 records were identified, out of
which 85 relevant studies were selected for qualitative synthesis following
PRISMA guidelines. The findings indicate that coordination compounds,
especially transition-metal complexes and metal–organic frameworks (MOFs),
exhibit high catalytic efficiency due to their tunable coordination
environments, variable oxidation states, and strong metal–ligand interactions.
These properties enable their effective use in key reactions such as
hydrogenation, oxidation, and carbon–carbon coupling. In parallel,
coordination-based systems demonstrate significant potential in targeted drug
delivery, offering high drug loading capacity, controlled release behavior, and
improved therapeutic specificity. Stimuli-responsive coordination frameworks
further enhance targeted delivery by enabling site-specific drug release under
physiological conditions. Comparative analysis reveals that the effectiveness
of coordination compounds in both domains is governed by common structural
attributes, including ligand design, coordination geometry, and electronic
configuration. Despite promising advancements, challenges such as toxicity,
stability, and scalability remain critical considerations for practical
applications. In conclusion, coordination compounds represent a powerful
platform bridging catalysis and biomedical science, with future prospects in
sustainable chemistry and precision medicine. Continued research in ligand
engineering, nanotechnology integration, and biocompatible material design is
expected to further expand their applicability.
Pages:39-43
How to cite this article:
Dr. Randhir Kumar "Comparative analysis of MOFs in chemical catalysis and biomedical applications". International Journal of Chemical Science, Vol 7, Issue 2, 2023, Pages 39-43
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