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VOL. 8, ISSUE 1 (2024)
Study of anti fungal activities of compounds involved in synthetic route of N-(4-Methoxyphenyl)-5-(Pyridin-4-Yl)- 1, 3, 4-oxadiazol-2-amine hemi hydro chloride mono hydrate
Authors
Sankatha Prasad Sonkar, Shailendra Yadav
Abstract
The antifungal activities of N-(4-Methoxyphenyl)-5-(Pyridin-4-Yl)-1, 3,
4-oxadiazol-2-amine hemihydrochloride monohydrate and compounds involved in its
synthetic route were investigated. Transition metal complexes formed with
nitrogen-rich ligands, particularly 1,3,4-oxadiazoles, have garnered
significant interest due to their diverse biological activities and
applications in various fields. The synthetic pathway involved four compounds,
with the final product obtained through cyclization by CoCl₂. The antifungal
efficacy was assessed against Candida species (Candida glabrata, Candida
albicans, Candida kefyr, and Candida krusei) using the Mueller Hinton agar
plate method at a concentration of 500 ppm. Results demonstrated that the final
compound exhibited substantial antifungal activity, comparable to Clotrimazole,
especially against Candida glabrata and Candida krusei, indicating its
potential as a promising antifungal agent.
Pages:41-43
How to cite this article:
Sankatha Prasad Sonkar, Shailendra Yadav "Study of anti fungal activities of compounds involved in synthetic route of N-(4-Methoxyphenyl)-5-(Pyridin-4-Yl)- 1, 3, 4-oxadiazol-2-amine hemi hydro chloride mono hydrate". International Journal of Chemical Science, Vol 8, Issue 1, 2024, Pages 41-43
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