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VOL. 8, ISSUE 2 (2024)
Advances in cyclodextrins: Enhancing drug solubility, stability, and bioavailability for therapeutic applications
Authors
M Jude Jenita
Abstract
Cyclodextrins (CDs) represent a versatile class of carrier molecules
that significantly enhance the pharmacokinetic profiles of therapeutic drugs.
These cyclic oligosaccharides are capable of forming inclusion complexes with
water-insoluble compounds, making them highly valuable in the fields of
medicine and pharmacology. Due to their unique structural properties,
cyclodextrins are extensively utilized in the pharmaceutical industry,
particularly in drug delivery systems. Their primary role in medicine is to
improve the solubility, stability, safety, and bioavailability of active
pharmaceutical ingredients (APIs). This article provides a comprehensive review
of the chemical structure, solubility, complexation behavior, and therapeutic
applications of cyclodextrins, focusing on their use as active pharmaceutical
ingredients in the treatment of various diseases, including viral infections,
metabolic disorders, and cardiovascular conditions. The review also explores
the structural characteristics, applications, and derivatives of cyclodextrins
in drug delivery, highlighting their potential to revolutionize therapeutic
interventions.
Pages:8-15
How to cite this article:
M Jude Jenita "Advances in cyclodextrins: Enhancing drug solubility, stability, and bioavailability for therapeutic applications". International Journal of Chemical Science, Vol 8, Issue 2, 2024, Pages 8-15
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