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VOL. 10, ISSUE 2 (2026)
Synthesis and antifungal activity of 1,3-Benzoxazole-5-carbonyl-pyridazine and phthalazine diones
Authors
Srinivas Katla, CH Sudhakar
Abstract
A series of novel
1,3-benzoxazole derivatives incorporating pyridazine and phthalazine dione
moieties were synthesized and evaluated for their antifungal potential. The
target compounds, 1-((2-substituted-1,
3-benzoxazol-5-yl)carbonyl)-1,2-dihydropyridazine-3,6-diones (6a-c),
1-((2-substituted-1, 3-benzoxazol-5-yl)carbonyl)tetrahydropyridazine-3,6-diones
(7a-c), and 2-((2-substituted-1,
3-benzoxazol-5-yl)carbonyl)-2,3-dihydrophthalazine-1,4-diones (8a-c), were
obtained through the condensation of 2-substituted benzoxazole-5-carboxylic
acid hydrazides with various cyclic anhydrides. The antifungal activity was
assessed against four pathogenic fungi: Candida albicans, Fusarium
oxysporium, Drechslera halodes, and Colletotrichum falcatum using the
cup-plate method. Among the screened compounds, 8b and 8c exhibited significant
antifungal activity, nearly equal to the standard drug Itrazole. These results
suggest that phthalazine-fused benzoxazole derivatives are promising leads for
the development of new antifungal agents.
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Pages:79-82
How to cite this article:
Srinivas Katla, CH Sudhakar "Synthesis and antifungal activity of 1,3-Benzoxazole-5-carbonyl-pyridazine and phthalazine diones". International Journal of Chemical Science, Vol 10, Issue 2, 2026, Pages 79-82
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