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VOL. 10, ISSUE 3 (2026)
Halogen-substituted schiff base and its Co(II), Ni(II), Cu(II), and Zn(II) complexes: Synthesis, structural elucidation, and anti- tubercular and anticancer studies
Authors
Ifat Md. Dafedar, Akshay A Ransing, Uzma K H Bangi, Hyung-Ho Park, Masidd Khalate, Sheetal D Gawali, Sadanand N Shringare
Abstract
Here in we prepared, a
Schiff base ligand synthesis from 2-hydroxybenzaldehyde and
3-choloro-4-fluoroaniline which was complexed with cobalt(II), Ni(II), Cu(II),
Zn(II).The obtained compound were characterized using a several spectroscopic
and physicochemical technique such as 1HNMR, HRMS,FTIR, UV, magnetic
susceptibility, TGA. The co-ordination of the ligand through azomethine
nitrogen and phenolic oxygen atoms was validated by FTIR measurements, which
were corroborated by the emergence of new M-N and M-O bands, the shift in the
(HC=N) band and the disappearance of the phenolic-OH proton upon complexation. Uv-visible
spectra and magnetic data showed suitable geometries surrounding the metal
centers. The thermogravimetric analysis show that the complexes are thermally
stable up to 200 °C followed by multi-step decomposition process that finally
yields the corresponding metal oxides. The biological studies showed that the
all compound possess anti-tubercular activity against mycobacterium
tuberculosis with inhibition increases as the concentration increases, among
them the Ni(II) complex exhibit comparatively higher activity. In addition the
anticancer study on the K562 cell line revealed a moderate to strong cytotoxic
response, the ligand itself performed better than most of the complexes,
although the Cu(II) complex also showed a meaningful level of activity. The
enhanced biological activity may be related to increased lipophilicity after
chelation which can enhance interaction with biological systems. Overall the
results indicate that the synthesized Schiff base and its metal complexes could
serve as potential candidates for further investigation as anti-tubercular and
anticancer agents.
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Pages:1-10
How to cite this article:
Ifat Md. Dafedar, Akshay A Ransing, Uzma K H Bangi, Hyung-Ho Park, Masidd Khalate, Sheetal D Gawali, Sadanand N Shringare "Halogen-substituted schiff base and its Co(II), Ni(II), Cu(II), and Zn(II) complexes: Synthesis, structural elucidation, and anti- tubercular and anticancer studies". International Journal of Chemical Science, Vol 10, Issue 3, 2026, Pages 1-10
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