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VOL. 10, ISSUE 2 (2026)
Design, synthesis, and biological evaluation of novel 6-aminobenzothiazole -based zink (Ii) metal complexes with anticancer, antimicrobial, adme applications and dna-binding studies
Authors
K Jagadesh babu, Koyada Vivek
Abstract
Two novel Zn(II) complexes derived from
6-aminobenzothiazole-based Schiff base ligands (HL1 and HL2)
were synthesized and comprehensively characterized using spectroscopic and
analytical techniques, including mass spectrometry, FT-IR, UV–Vis spectroscopy,
magnetic susceptibility, and thermogravimetric analysis (TGA). The complexes,
formulated as [Zn(HL)₂(H₂O)₂], were found to exhibit a six-coordinate
octahedral geometry. DNA binding studies suggested an intercalative interaction
mode for the complexes, with binding constants (Kₐ) following the order 2a >
1a, as determined by UV absorption and emission experiments. In DNA cleavage
assays, the complexes demonstrated higher efficiency in cleaving
double-stranded pBR322 DNA through oxidative and photolytic methods compared to
their parent Schiff base. Cytotoxicity assays against A549 and MCF7 cell lines
showed enhanced activity for the complexes relative to the free ligands.
Additionally, In-vitro
antimicrobial studies confirmed the superior efficacy of the complexes over the
ligands. The biological efficacy of the ligands (HL1 & HL2)
and their complexes (1a & 2a) was further validated through computational
methods, including ADME analysis using the SWISS ADME tool. The in silico
studies indicated that both the ligands and complexes exhibit drug-like
properties and promising bioavailability, highlighting their potential as oral
drugs.
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Pages:95-105
How to cite this article:
K Jagadesh babu, Koyada Vivek "Design, synthesis, and biological evaluation of novel 6-aminobenzothiazole -based zink (Ii) metal complexes with anticancer, antimicrobial, adme applications and dna-binding studies". International Journal of Chemical Science, Vol 10, Issue 2, 2026, Pages 95-105
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